Mini Core Facility

 Original:  https://rupress.org/jcb/article/225/3/e202601032/281525/Better-reporting-is-better-science-Community จริง ๆ แล้วเคยเอาไกด์ไลน์ลักษณะนี้แปะไว้ในบล็อกนี้ เพื่อเพิ่มประสิทธิภาพในการจัดการบริหารเครื่องมือที่ดูและอยู่ โดยเฉพาะเรื่องกล้องจุลทรรศน์ที่ดูแลอยู่ (ลิงค์ที่เกี่ยวข้องอยู่ข้างล่าง) รายงานสรุป: ข้อกำหนดขั้นต่ำในการรายงานข้อมูลกล้องจุลทรรศน์ (Bare Minimal Microscopy Reporting Requirements) 1. บทนำและความสำคัญของความโปร่งใสในงานวิจัยด้านกล้องจุลทรรศน์ กล้องจุลทรรศน์เป็นหัวใจสำคัญของการค้นพบในวิทยาศาสตร์ชีวการแพทย์และชีวิต แต่ความก้าวหน้าทางเทคโนโลยีที่รวดเร็วมักสวนทางกับคุณภาพของการรายงานข้อมูล ปัญหาการรายงานข้อมูลที่ไม่สมบูรณ์ ( Incomplete reporting ) บั่นทอนความโปร่งใสและบิดเบือนความสามารถในการทำซ้ำ ( Reproducibility ) ของงานวิจัย ในปัจจุบัน นักวิจัยจำนวนมากตกอยู่ภายใต้ความกดดันที่ต้องตีพิมพ์ผลงานอย่างรวดเร็ว (Rapid publication pressure) และการขาดการฝึกอบรมเชิงลึก ทำให้กล้องจุลทรรศน์ถูกมองว่าเป็นเพียง "กล่องดำ" (Black boxes) ที่ผลิตภาพออกมาโดยผู้ใช้ไม่เข้าใจถึงอ...

I think this is a very good example how to manage the core facilitis/research infrastructure across the European region. Asean, esp, SEA is very fragmented. Original link:  https://lifescience-ri.eu/home.html

We are excited to share with you the first iSEA Conference 2025! Theme: Building Imaging Networks Across Southeast Asia Date: 12–13 November 2025 Venue: Monash University Malaysia Join imaging scientists, core facility staff, researchers, and early-career professionals from across Southeast Asia and beyond to explore how regional collaboration is shaping the future of bioimaging. This two-day in-person event will feature: Regional & global updates from imaging networks Interactive sessions on facility sustainability, training, and data management Insights into shared infrastructure and open science in imaging A growing community advancing microscopy, image analysis, and more Whether you’re building a core facility, running cutting-edge imaging, or mentoring the next generation—this is the place to connect, learn, and lead. Travel Support for Southeast Asian Participants Travel grants will be made available to eligible participants based in Southeast Asia. Further information, ...

We're promoting the Acknowledgment Guidelines by the Royal Microscopical Society ( https://www.rms.org.uk/ ) and Global BioImaging   ( https://globalbioimaging.org/ ) at our bioimaging facility, located within the Offices of Health Science Research, Faculty of Medicine Ramathibodi Hospital, Mahidol University. As part of the iSEA network ( https://www.imagingsea.org/ ), our small lab is committed to advancing our image core's practices to align with both regional and global best standards. We also want to express our appreciation for the dedicated individuals who maintain our imaging platform and provide essential academic support for health research. You can download the general guidelines here: https://globalbioimaging.org/documents/imaging-facility-guidelines Our facility's specific regulations, which comply with these guidelines, are available here: https://www.rama.mahidol.ac.th/ramacloud/s/QuEavNgsKGJSrMQ แนวทางการเขียนกิติกรรมประกาศของศูนย์ถ่ายภาพเพื่องานวิจัยทางว...

Below is the slide from this meeting "การประชุม เรื่อง “ยุทธศาสตร์ด้านการวิจัยมหาวิทยาลัยมหิดลเพื่อมุ่งสู่ Real World Impact” วันพฤหัสบดีที่ 17 ตุลาคม พ.ศ. 2567 เวลา 09.30 – 11.30 น. https://drive.google.com/file/d/1hbqWH9of26DWBc0YtFtRntZ25aj8-T8X/view It is pretty cool that Gemini can inform you on the directions of research environment management.  Q: The image displays "The World University Rankings 2025" with a section highlighted in red, specifically focusing on "2 Research Environment" and "3 Research Quality." Research Environment "Research Environment" is one of the pillars used in the university ranking, carrying a weighting of 29%. This pillar likely assesses factors that contribute to a university's ability to conduct high-quality research, such as: Research infrastructure: Access to state-of-the-art laboratories, equipment, and resources. Funding and investment: The level of financial support for research activities. Re...

 https://onlinelibrary.wiley.com/doi/10.1111/jmi.13307 https://www.nature.com/articles/s41592-024-02397-1?fbclid=IwY2xjawGD68BleHRuA2FlbQIxMQABHUGehtv-4RHAs4AOA3_XPwr3elxE1aIY3Xzp9UqjeGZ7k-bL9afjHcCefg_aem_zOBSsOeIZ7RZOXrAlXFwQA#Sec5 https://www.nature.com/articles/s41592-025-02690-7 -- I have already pointed out in the report after attending the Okinawa Microscopy Workshop 2024 :

Below are examples of publicly available user policies for developing guidelines to use with our Bioamge Facility, which I have taken care of. https://nic.botany.wisc.edu/ nic-guidelines/ https://www.med.unc.edu/ neuroscience/neuro-microscopy/ user-info/core-policies/ https://groups.oist.jp/img https://science.mahidol.ac.th/ scre/cif/?page_id=678&lang=en https://simba-mbi.com/code-of- conduct https://microscopy.duke.edu/rules Our policy

I cannot download the full text, but the pre-prine version is freely available. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11118354/ The tenure track is very limited, thus generating a post-doc crisis in which the majority cannot compete for the tenure track. They are looking for alternative career paths and focusing in-depth on their technical skill sets. Consequently, the group launched post-doc training on bioimage analysis, where this technique becomes more important in several industries as well as in academic environments, like core facilities. As of now, I don't see a real core facility in Thailand, only the custodians who take care of instruments but don't have in-depth knowledge of the technical part as well as data analysis related to the particular instruments.

Eligibility 1.You must be employed by a nonprofit research institution (institute, university, etc.) 2.You work in one of the following: An imaging core facility as a director, manager, or staff member A research lab with imaging as a central focus where you provide access to microscopy and/or biomedical imaging technologies to researchers in your institution and/or other institutions 3.To ensure fair distribution of travel grants, if you have been awarded a travel grant by Global BioImaging within the last 18 months, you are not eligible to apply. Application form: https://forms.gle/xpLgKsbF68rABNo79 Application deadline: 9 September 2024 More detail on:  https://globalbioimaging.org/international-job-shadowing-program/open-call-2024

  https://globalbioimaging.org/international-training-courses/gbi-singascope-2024-course The deadline is 8 July 2024. Currently, only Singapore has a well-established Bioimage core within the Southeast Asia region. Sooner or later, Malaysia will be next. (accessed date: 2024-June-23) I have raised the issue regarding establishing the core here at RC. So far, no progress.

Molecules to Human (M2H) boot camp The M2H boot camp aims to deliver  theoretical and hands-on training  in several  light microscopy and biomedical imaging  (preclinical/animal imaging) technologies. Topics such as introduction to research models, identification of most suitable imaging workflows and image analysis strategies, research project management, data management, and image analysis will also be featured at the course. The M2H boot camp will feature  24 participants  from across the globe.   The M2H boot camp is open to applicants who have theoretical and hands-on experience in one imaging field (light microscopy or biomedical imaging) and would like to use second imaging field in their research in which they currently do not have expertise.   The M2H boot camp, fully funded by  Chan Zuckerberg Initiative , will take place in  Denmark  on  16-27 September 2024  hosted by a Euro-BioImaging Node in Denmark...

Rarely seen this analysis from our leader's vision. Mostly seen from the US/European side.

Mahidol University Frontier Research Facility Loading… Link:  https://online.anyflip.com/xnevg/vniq/mobile/index.html Service fee:  https://minicore-rarc.blogspot.com/2024/02/instrument-service-fee-at-cif-salaya.html MUREX:  https://mahidol.elsevierpure.com/en/organisations/research-management-and-development-division/equipments/ Acknowledgement Policy for MU-FRF

 

A very good suggested guideline article for publishing microscope image data: check out Nature Method. Community-developed checklists for publishing images and image analyses https://www.nature.com/articles/s41592-023-01987-9 As of now, our facility still lacks "Quality Assessment and Reproducibility for Instruments & Images in Light Microscopy (QUAREP-LiMi)" , and I don't see any support from any leader at any level so far --- yet, the University would like us to have good quality research. As I have asked the distributors (4 distributors -- Nikon, Leica, Olympus, and ZEISS), none of them have known this issue, and the specialists lack the program to initiate it. This is because it has costs, and they don't know whether each central facility in each University would like to have this. If no customer, it is worthless for them to initiate this service, thus the core must do it by itself, and it requires skilled personnel and financial support. Old blogs related to ...

 Practical Guide to Storage of Large Amounts of Microscopy Data 10.1017/S1551929520001091 Factors to Consider When Selecting Student Microscopes for Schools and Universities 10.1017/S155192951800144X How to Get Better Fluorescence Images with Your Widefield Microscope: A Methodology Review 10.1017/S155192952000156X Practical Guide to Choosing a Microscope Camera 10.1017/S155192951700061X An Image is Everything: A Tutorial on Choosing and Using the Components of a Dynamic Data Capture System 10.1017/S1551929520001558 Scientific Ethics: What Are Our Responsibilities As Facility Managers? M&M 2001 Expert's Session on Core Facility Management 10.1017/S1551929500057795 Practical Guide to Storage of Large Amounts of Microscopy Data 10.1017/S1551929520001091 Best practices and tools for reporting reproducible fluorescence microscopy methods 10.1038/s41592-021-01156-w

  Super Small Research Facility at Ramathibodi Hospital -- Microbiology Area

This is a great video worth watching and learning from.  Ref: https://www.molbiolcell.org/doi/10.1091/mbc.E20-03-0167 Research Center Safety Website: https://sites.google.com/site/rclabsafety/ It is kind of awkward a bit that we don't have an official website. I have made it by myself for the sake of introducing a safety culture to the research center!

We read a lot of research papers but we do not pay attention that much to infrastructure management, especially core facilities. Actually, there are several papers or articles published recently on how to run core effectively and how good facility management helps on research productivity and reproducibility. Scopus search ~ keyword: core facility management; many good articles listed by scanning the QR code below

A good article that should be read for the person who would like to have a good core facility and reproducibility in research. I rarely see (here) the executive board paying attention to this but rather focusing on a number of publications, just for climbing the ranking - building the house of card? https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(20)30119-7?dgcid=raven_jbs_etoc_email#back-bb0035 doi:  10.1016/j.tcb.2020.06.001 The main structure - The author also has the micro-courses on the microscope. It is very useful. Check the below link. https://www.youtube.com/c/Microcourses/featured Rigor and reproducibility ~  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657953/